Inspire Faculty


Faculty Details

  • Qualification Ph.D.
  • Email asiyabatool16@gmail.com

The intricacy and plasticity of oncogenic signalling networks has emerged as an inevitable mechanism of acquired resistance to targeted cancer therapies. One such mechanism is the sustained activation of oncogenic translation programs due to dysregulation of translational factors. Conceptual progress in the last decade has added to the oncogenic stature of translational factors. In light of this, we have deciphered a close integration of MNK1 and mTORC1 signals that activate Eukaryotic Translation Initiation Factor (eIF4E) to regulate the physiological state of the cell by synchronizing protein translation with cancer cell progression. We believe that translational dysregulation endows functional diversity of tumorigenesis to regulate cancer cell proliferation and unabated cell division in tandem. We aim in understanding and targeting the oncogenic translational network that selectively influences the tumor cell survival. Our work focusses on:

  • Piercing the dark matter for visualizing the chaos of cancer cell.
  • Providing snapshots of stable and transient interactions of mTOR signalling pathway to expand our understanding of mTOR biology.
  • Identification of robust genetic relationships selectively influencing tumor cell survival for converting malignancies to benignity.
  • Identification of newer targets to diversify chemo-therapeutic platform for making Cancer Vaccines.

 

SELECT PUBLICATIONS

  • Batool A, Sheikh Tahir Majeed, Sabreena Aashaq, Rabiya Majeed, Ghazia Shah, Nadiem Nazir, and Khurshid Iqbal Andrabi. Eukaryotic initiation factor 4e (eif4e) sequestration mediates 4e-bp1 response to rapamycin. International Journal of biological macromolecules, 125:651–659, 2019.
  • Batool A, Sheikh Tahir Majeed, Sabreena Aashaq, Rabiya  Majeed,  Nadiem  Nazir  Bhat,  and  Khurshid Iqbal Andrabi.  Eukaryotic initiation factor 4e is a novel effector of mtorc1 signaling pathway in crosstalk with mnk1. Molecular and Cellular Biochemistry, 465(1-2):13–26, 2020.
  • Batool A, Sheikh Tahir Majeed, Sabreena Aashaq, Rabiya Majeed, and Khurshid Iqbal Andrabi. Eukaryotic initiation factor 4e phosphorylation acts a switch for its binding to 4e-bp1 and mrna cap assembly. Biochemical and Biophysical Research Communications, 2020.
  • Majeed ST, Batool A, Rabiya Majeed, Nadiem Nazir Bhat, Afzal Zargar and Khurshid Iqbal Andrabi.  mTORC1 induces eukaryotic translation initiation factor 4E interaction with TOS-S6 kinase 1 and its activation. Cell Cycle (2021) doi: 10.1080/15384101.2021.1901038
  • Batool A, Malik F, Andrabi KI. Expansion of the CRISPR/Cas Genome-Sculpting Toolbox: Innovations, Applications and Challenges. Molecular Diagnosis & Therapy. 2020 Nov 13:1-7.
  • Batool A, Sabreena Aashaq, and Khurshid I Andrabi.  Eukaryotic initiation factor 4e (eif4e):  A recap of the cap-binding protein. Journal of cellular biochemistry, 120(9):14201–14212, 2019.
  • Batool A, Sabreena Aashaq, and Khurshid Iqbal Andrabi. Reappraisal to the study of 4e-bp1 as an mtor substrate–a normative critique. European Journal of Cell Biology, 96(4):325–336, 2017.
  • Aashaq, S., Batool A, Mir S, Beigh M, Andrabi, K.I and Amin Z; 2021 TGF- β signalling – A recap of SMAD independent and SMAD dependent pathways Journal of Cellular Physiology
  • Aashaq S, Batool A, Andrabi KI. TAK1 mediates convergence of cellular signals for death and survival. Apoptosis. 2019 Feb;24(1):3-20.
  • Rafiq D, Batool A, Bazaz MA. Three months of COVID‐19: A systematic review and meta‐analysis. Reviews in Medical Virology. 2020 Jul;30(4):e2113.
  • Showkat M, Beigh MA, Bhat BB, Batool A, Andrabi KI. Phosphorylation dynamics of eukaryotic initiation factor 4E binding protein 1 (4E-BP1) is discordant with its potential to interact with eukaryotic initiation factor 4E (eIF4E). Cellular signalling. 2014 Oct 1;26(10):2117-21.
  • Aashaq, S., Batool A,. and Andrabi, K.I., 2018 Deletion Mutagenesis of TAK1: Role of TAB1 as an Activator International Journal of Life Sciences Research Vol. 6, Issue 3, pp: (91-99)

AWARDS AND HONOURS 

  • Gold Medal & Certificate of Distinction (1st Class 1st Rank in the M.Sc. Programme)
  • Recipient of INSPIRE Faculty post-doctoral fellowship 2020 sponsored by DST-India (LSBM/243/2020/000137)
  • Recipient of National Post-doctoral fellowship (NPDF) sponsored by DST-SERB 2021 (PDF/2021/001305)
  • Recipient of Research associateship sponsored by Department of Biotechnology, Govt. of India, 2019
  • Recipient of INSPIRE doctoral fellowship (JRF and SRF) 2014 sponsored by DST-India (IF140150/2014)
  • State rank holder (3rd rank) at Undergraduate (B.Sc.) level University exam.
  • Merit holder (Top 1%) at 12th class Examination
  • Merit holder (Top 1%) at 10th class Examination
  • Highest scorer in Science at state level Matric Examination
  • Qualified National Eligibility Test (NET-LS) twice in 2012 and 2013 conducted by CSIR, India.
  • Qualified State Eligibility Test (JKSET) in 2013 conducted by University of Kashmir, India
  • Qualified Graduate Aptitude Test in Engineering (GATE-2012) with 98.5 percentile conducted by IIT-Delhi, India
  • Qualified ASRB-NET (2012) conducted by Agricultural Scientist Recruitment Board, Department of Agricultural Research (ICAR), India
  • Awarded with highest read/downloaded paper of the year (2018-2019) by Wiley Journal of Cellular Biochemistry (IF 4.2)
  • Awarded with first prize for paper presented in 13th annual JK Science Congress in 2018.